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KMID : 0390119940340010127
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Journal of Pusan Medical College
1994 Volume.34 No. 1 p.127 ~ p.132
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Clinical significance of PIVKA-II in patients with hepatocelluar carcinoma
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Abstract
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Des γ0carboxyprothrombin(PIVKA-II) was detected in 43 of 83 patents (52%) with hepatocelluar carcinoma(HCC) and its concentrations were high in about three fourths of these PIVKA-II positive patients.
In only 4 percent of patients with chronic hepatitis and liver cirrhosis, PIVKA-II was found and its concentrations were low. PIVKA-II was not detected in patients with cancers other than liver cancers and normal subjects. There was no
correlation
between AFP and concentrations of PIVKA-II. Concentrations of PIVKA-II changed closely in parallel with development of HCC and its treatments, surgical resection of tumors and L-TAI. Detection of PIVKA-II will be valuable in the diagnosis and
follow-up
of HCC.
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KEYWORD
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